One of many main problems with drug supply is the inability of enormous hydrophilic compounds to pass by the lipid membrane of the cell, thus making drugs equivalent to polypeptides and oligonucleotides of restricted therapeutic value. Till not too long ago, the transport of such molecules into the cytoplasmic and nuclear compartments of dwelling cells appeared a distant goal. Therefore, the invention that peptides derived from the HIV Tat protein and homeodomain of the Antennapedia transcription issue (penetratin) can translocate throughout the plasma membrane of stay cells has opened up exciting new potentialities in biomedical research.
This book fills the need for a comprehensive replace of the research concerning these specialised peptides, referred to as cell-penetrating peptides (CPPs), to which the drug molecule can attach and go by means of the cell membrane. Divided into three parts, Cell-Penetrating Peptides: Processes and Applications covers lessons of cell-penetrating peptides; mechanisms of cell penetration, interactions of cell-penetrating peptides with plasma membranes, and lipid models; and purposes of cell-penetrating peptides. These divisions cover all data from primary biochemistry to clinical software, including a transparent description of the general guidelines for cellular uptake of the transport peptides. The overview of work in this space will result in better designed novel transport peptides to attain the extra profitable software of CPPs in research and therapy.
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