Edward J. Massaro and a panel of main biomedical researchers and scientific practitioners overview, in-depth, the status of our present knowledge regarding the biochemistry of copper on the whole and its role in health and illness in particular. Drawing on the wealth of latest info rising from the molecular biology revolution, these specialists survey an important research areas of copper pharmacology and toxicology, together with copper proteins and transport, copper toxicity and therapeutics, and copper metabolism and homeostasis. They also talk about the molecular pathogenesis of copper in a variety of metabolic illnesses, Menkes and Wilson's ailments and occipital horn syndrome, in addition to the function of copper in Parkinson's illness, prion disease, familial amytrophic lateral sclerosis (ALS), and Alzheimer's disease.
Review
"...biochemical and molecular researchers from across the globe have produced 35 chapters documenting the current state of data in chosen areas of copper pharmacology and toxicology. the state-of-the-art knowledge supplied will little question stimulate difficult research with this important hint ingredient required by organism starting from micro organism to mammals." - Veterinary and Human Toxicology "The ebook has excellent introductory chapters, and summarizes a lot latest research at the genetic and cellular levels." - Newsletter of the British Toxicological Society "Dr. Massaro have to be congratulated for enhancing this comprehensive e-book on copper. There are so many outstanding chapters in this compendium that highlighting any certainly one of them mustn't detract from the others...this e book is a treasure trove of references. The value of the e book, though modest for this compendium could be justified for the Preface and the primary chapter alone. This book is extremely recommended. At the present time it has no equal." -Worldwide Journal of Toxicology
From the Again Cover
Though copper is an important hint factor obligatory for the survival of organisms ranging from micro organism to mammals, it is also highly toxic and have to be absorbed by the physique in precisely orchestrated biological processes. In Handbook of Copper Pharmacology and Toxicology, Edward J. Massaro and a panel of leading biomedical researchers and medical practitioners evaluate, in-depth, the standing of our current information concerning the biochemistry of copper generally, and its function in health and illness in particular. Drawing on the wealth of new data emerging from the molecular biology revolution, these specialists survey crucial research areas of copper pharmacology and toxicology, together with copper proteins and transport, copper toxicity and therapeutics, and copper metabolism and homeostasis. In addition they discuss the molecular pathogenesis of copper in quite a lot of metabolic illnesses-Menkes and Wilson's illnesses and occipital horn syndrome-in addition to the role of copper in Parkinson's disease, prion illness, familial amyotrophic lateral sclerosis (ALS), and Alzheimer's disease. The elucidation of the precise mechanisms of copper trafficking, metabolism, and homeostasis will probably be of appreciable importance in understanding the pathophysiology and treatment of such diseases. Comprehensive and well timed, the Handbook of Copper Pharmacology and Toxicology authoritatively gives researchers with all of the up-to-date info wanted to work productively in copper biology today.
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