A complete information to drug transporters that influence the absorption, distribution, and elimination of medication in the physique
The development of highly effective expression cloning and genome evaluation strategies has facilitated the molecular identification and characterization of quite a few transporters that play an important position in drug disposition. Explaining the principles of drug transport and the related techniques, Drug Transporters: Molecular Characterization and Position in Drug Disposition:
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Provides a comprehensive overview of drug transporters
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Contains particular descriptions of transporter households, together with substrate and inhibitor specificity, subcellular and tissue localization, mechanisms governing transport, species variations, the scientific implications of these transporters in human physiology and illness, and their function in drug distribution, elimination, and interactions in drug therapy
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Describes transporter-mediated drug disposition, a newly emerging discipline in drug remedy
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Gives a complete summary of drug transport across organic membranes
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in the liver, brain, kidney, and gut
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Gives balanced coverage of mechanistic aspects and practical outcomes
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Features chapters contributed by distinguished scientists of their specialty areas
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Offers enough element to enable non-specialists to grasp the rules and strategies
This authoritative information is a practical palms-on desk reference for researchers in academia and the pharmaceutical trade and scientists in government agencies. It is usually a wonderful text for graduate-degree programs in the pharmaceutical and pharmacology fields.
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